Procalcitonin for Reduced Antibiotic Exposure in Ventilator Associated Pneumonia - A Randomized Study
نویسندگان
چکیده
Daiana Stolz, M.D., 2 Nicholas Smyrnios, M.D., Philippe Eggimann, M.D., Hans Pargger, M.D., Nehal Thakkar, M.D., Martin Siegemund, M.D., 5 Stephan Marsch, M.D., 6 Janko Rakic, M.D., 1 Beat Mueller, M.D., and Michael Tamm, M.D. 1 From the Clinic of Pulmonary Medicine, 1 Division of Anesthesiology and Surgical Intensive Care Medicine, Division of Medical Intensive Care Medicine, 6 Basel CH-4031, Switzerland; Department of Internal Medicine, Kantonsspital, CH-5001 Aarau, Switzerland; the Division of Pulmonary, Allergy and Critical Care Medicine, 3 UMass Memorial Medical Center, 01655 Worcester, MA, USA; the Department of Adult Critical Care Medicine, 4 University Hospital, CH-1011 Lausanne, Switzerland; and the Harvard School of Public Health, 2 02115, Boston, MA, USA
منابع مشابه
Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study.
In patients with ventilator-associated pneumonia (VAP), guidelines recommend antibiotic therapy adjustment according to microbiology results after 72 h. Circulating procalcitonin levels may provide evidence that facilitates the reduction of antibiotic therapy. In a multicentre, randomised, controlled trial, 101 patients with VAP were assigned to an antibiotic discontinuation strategy according ...
متن کاملEffect of vitamin D supplementation on procalcitonin as prognostic biomarker in patients with ventilator associated pneumonia complicated with vitamin D deficiency
Ventilator-associated pneumonia (VAP) is a common and serious problem that develops after more than 48 hours of mechanical ventilation. Improving the activity of immune system with vitamin D, and its consequent impact on prognostic biomarkers of VAP was studied in the current study. A randomized double blind placebo controlled clinical trial was designed. A total of 46 patients with VAP, who w...
متن کاملEffect of vitamin D supplementation on procalcitonin as prognostic biomarker in patients with ventilator associated pneumonia complicated with vitamin D deficiency
Ventilator-associated pneumonia (VAP) is a common and serious problem that develops after more than 48 hours of mechanical ventilation. Improving the activity of immune system with vitamin D, and its consequent impact on prognostic biomarkers of VAP was studied in the current study. A randomized double blind placebo controlled clinical trial was designed. A total of 46 patients with VAP, who w...
متن کامل[Role of plasma procalcitonin in the diagnosis of ventilator-associated pneumonia: systematic review and metaanalysis].
OBJECTIVE To determine the role of plasma procalcitonin (PCT) levels in diagnosing ventilator-associated pneumonia. DESIGN A systematic review of publications prospectively assessing the diagnostic role of PCT in ventilator-associated pneumonia was carried out. The search was performed using Medline, Embase, the Cochrane Collaboration and MEDION, with reviewing of the references of retrieved ...
متن کاملProcalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial.
RATIONALE In patients with community-acquired pneumonia, guidelines recommend antibiotic treatment for 7 to 21 d. Procalcitonin is elevated in bacterial infections, and its dynamics have prognostic implications. OBJECTIVE To assess procalcitonin guidance for the initiation and duration of antibiotic therapy in community-acquired pneumonia. METHODS In a randomized intervention trial, 302 con...
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